In 1976 Zolla/Lieberman Gallery moved to a converted loft space in a then desolate industrial neighborhood and founded the area that is now known as the River North Gallery District. It was in that inaugural year that Zolla/Lieberman Gallery gave a solo show to an unknown artist named Deborah Butterfield.

Today, at their current location at 325 W. Huron St., William continues to maintain the aesthetic quality of contemporary artwork that the history of the gallery had established since its opening. By embracing a wide range of genres and artists, Z/L is able to offer a variety of work. Zolla/Lieberman Gallery is dedicated to providing personal attention to both the beginning and established collector, as well as other art professionals. Z/L maintains professional associations with the Art Dealers Association of America (ADAA) and the Chicago Art Dealers Association (CADA), as well as being a participant of Art Chicago since its conception.